Endocrine Abstracts

Background and aims: Obesity is a chronic multifactorial disease characterized by an excessive accumulation of body fat resulting from an imbalance between energy intake and caloric expenditure. Uncoupling protein 2 (UCP2) is located in the inner mitochondrial membrane and plays an important role in the regulation of energy expenditure. NLR family, pyrin domain-containing 3 (NLRP3) inflammasome seems to have a key role in obesity-induced inflammation through production of the ...

Background and aims: In adipose tissue, excess of energy is stored inside cytosolic lipid droplets as triglycerides. During fasting or exercise, the stored fat is mobilized for utilization as free fatty acids and glycerol via lipolysis. The complete lipolysis of triglycerides is mediated by the orchestrated activation of adipose triglyceride lipase (ATGL) and hormone-sensitive lipase, which have been associated with obesity. There is compelling evidence that the protein compar...